DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience.

ABSTRACT: Dopamine (DA) neurotransmission through D2 receptors (DRD2) has been implicated in the regulation of reward processing, cognition and the effects of drugs of abuse, and also has significant effects in responses to stressors and salient aversive stimuli. An examination of the influence of genetic variation across multiple psychophysical measures therefore appears critical to understand the neurobiology of DA-modulated complex personality traits and psychiatric illnesses. To examine inter-individual variation in the function of DRD2 modulated mechanisms in healthy humans, we used a haplotype-based and single nucleotide polymorphism (SNP) investigation. Their effects were interrogated with functional magnetic resonance imaging during reward and emotional processing. We found that a haplotype

SUBMITTER: Pecina M 

PROVIDER: S-EPMC3381848 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature