Genetic interactions with mutations affecting septin assembly reveal ESCRT functions in budding yeast cytokinesis.

ABSTRACT: Membrane trafficking via targeted exocytosis to the Saccharomyces cerevisiae bud neck provides new membrane and membrane-associated factors that are critical for cytokinesis. It remains unknown whether yeast plasma membrane abscission, the final step of cytokinesis, occurs spontaneously following extensive vesicle fusion, as in plant cells, or requires dedicated membrane fission machinery, as in cultured mammalian cells. Components of the endosomal sorting complexes required for transport (ESCRT) pathway, or close relatives thereof, appear to participate in cytokinetic abscission in various cell types, but roles in cell division had not been documented in budding yeast, where ESCRTs were first characterized. By contrast, the septin family of filament-forming cytoskeletal proteins were firs

SUBMITTER: McMurray MA 

PROVIDER: S-EPMC3381890 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature