Formin mDia1 mediates vascular remodeling via integration of oxidative and signal transduction pathways.

ABSTRACT:

Rationale

The mammalian diaphanous-related formin (mDia1), governs microtubule and microfilament dynamics while functioning as an effector for Rho small GTP-binding proteins during key cellular processes such as adhesion, cytokinesis, cell polarity, and morphogenesis. The cytoplasmic domain of the receptor for advanced glycation endproducts binds to the formin homology 1 domain of mDia1; mDia1 is required for receptor for advanced glycation endproducts ligand-induced cellular migration in transformed cells.

Objective

Because a key mechanism in vascular remodeling is the induction of smooth muscle cell migration, we tested the role of mDia1 in this process.

Methods and results

We report that endothelial denudation injury to the murine femoral artery significantly upreg

SUBMITTER: Toure F 

PROVIDER: S-EPMC3381909 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature