Semantic integration of physiology phenotypes with an application to the Cellular Phenotype Ontology.

ABSTRACT:

Motivation

The systematic observation of phenotypes has become a crucial tool of functional genomics, and several large international projects are currently underway to identify and characterize the phenotypes that are associated with genotypes in several species. To integrate phenotype descriptions within and across species, phenotype ontologies have been developed. Applying ontologies to unify phenotype descriptions in the domain of physiology has been a particular challenge due to the high complexity of the underlying domain.

Results

In this study, we present the outline of a theory and its implementation for an ontology of physiology-related phenotypes. We provide a formal description of process attributes and relate them to the attributes of their temporal parts and par

SUBMITTER: Hoehndorf R 

PROVIDER: S-EPMC3381966 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature