Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onset.

ABSTRACT:

Objectives

To test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression.

Design

Measurement of cognition both before and following 12 weeks of treatment with sertraline.

Setting

University medical centers (Washington University and Duke University).

Participants

One hundred sixty-six individuals with late-life depression.

Intervention

Sertraline treatment.

Measurements

The cognitive tasks were grouped into five domains (language, processing speed, working memory, episodic memory, and executive function). We measured vascular risk using the Framingham Stroke Risk Profile measure. We measured T2-based white matter hyperinte

SUBMITTER: Barch DM 

PROVIDER: S-EPMC3382028 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature