Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants.

ABSTRACT:

Background

Established psychosocial risk factors increase the risk for experimentation among Mexican origin youth. Now, we comprehensively investigate the added contribution of select polymorphisms in candidate genetic pathways associated with sensation seeking, risk taking, and smoking phenotypes to predict experimentation.

Methods

Participants (N = 1,118 Mexican origin youth) recruited from a large population-based cohort study in Houston, TX, provided prospective data on cigarette experimentation over 3 years. Psychosocial data were elicited twice-baseline and final follow-up. Participants were genotyped for 672 functional and tagging variants in the dopamine, serotonin, and opioid pathways.

Results

After adjusting for gender and age, with a Bayesian False Discover

SUBMITTER: Wilkinson AV 

PROVIDER: S-EPMC3382046 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature