The peripheral blood transcriptome identifies the presence and extent of disease in idiopathic pulmonary fibrosis.

ABSTRACT:

Rationale

Peripheral blood biomarkers are needed to identify and determine the extent of idiopathic pulmonary fibrosis (IPF). Current physiologic and radiographic prognostic indicators diagnose IPF too late in the course of disease. We hypothesize that peripheral blood biomarkers will identify disease in its early stages, and facilitate monitoring for disease progression.

Methods

Gene expression profiles of peripheral blood RNA from 130 IPF patients were collected on Agilent microarrays. Significance analysis of microarrays (SAM) with a false discovery rate (FDR) of 1% was utilized to identify genes that were differentially-expressed in samples categorized based on percent predicted D(L)CO and FVC.

Main measurements and results

At 1% FDR, 1428 genes were differentiall

SUBMITTER: Yang IV 

PROVIDER: S-EPMC3382229 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature