The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum.

ABSTRACT:

Background

The mitochondrial genome in the human malaria parasite Plasmodium falciparum is most unusual. Over half the genome is composed of the genes for three classic mitochondrial proteins: cytochrome oxidase subunits I and III and apocytochrome b. The remainder encodes numerous small RNAs, ranging in size from 23 to 190 nt. Previous analysis revealed that some of these transcripts have significant sequence identity with highly conserved regions of large and small subunit rRNAs, and can form the expected secondary structures. However, these rRNA fragments are not encoded in linear order; instead, they are intermixed with one another and the protein coding genes, and are coded on both strands of the genome. This unorthodox arrangement hindered the identification of transcripts co

SUBMITTER: Feagin JE 

PROVIDER: S-EPMC3382252 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature