Computing the protein binding sites.

ABSTRACT:

Background

Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions. Therefore, efficient methods are required if all these structures are to be properly annotated. Lots of methods for finding binding sites involve 3D structure comparison. Here we design a method to find protein binding sites by direct comparison of protein 3D structures.

Results

We have developed an efficient heuristic approach for finding similar binding sites from the surface of given proteins. Our approach consists of three steps: local sequenc

SUBMITTER: Guo F 

PROVIDER: S-EPMC3382440 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature