IRhom2 is required for the secretion of mouse TNFα.
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ABSTRACT:
SUBMITTER: Siggs OM
PROVIDER: S-EPMC3382936 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
iRhom2 is required for the secretion of mouse TNFα.
Siggs Owen M OM Xiao Nengming N Wang Ying Y Shi Hexin H Tomisato Wataru W Li Xiaohong X Xia Yu Y Beutler Bruce B
Blood 20120501 24
TNFα is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFα secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages. A missense mutation was revealed in the gene encoding the inactive rhomboid protease iRhom2, which was not complemented by a null allele of the same gene. Neither the missense nor the null allele af ...[more]
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