Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641.

ABSTRACT:

Purpose

The primary objective of Children's Oncology Group study P9641 was to demonstrate that surgery alone would achieve 3-year overall survival (OS) ≥ 95% for patients with asymptomatic International Neuroblastoma Staging System stages 2a and 2b neuroblastoma (NBL). Secondary objectives focused on other low-risk patients with NBL and on those who required chemotherapy according to protocol-defined criteria.

Patients and methods

Patients underwent maximally safe resection of tumor. Chemotherapy was reserved for patients with, or at risk for, symptomatic disease, with less than 50% tumor resection at diagnosis, or with unresectable progressive disease after surgery alone.

Results

For all 915 eligible patients, 5-year event-free survival (EFS) and OS were 89% ± 1% and

SUBMITTER: Strother DR 

PROVIDER: S-EPMC3383182 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature