Targeted therapy for glioma using cyclic RGD-entrapped polyionic complex nanomicelles.

ABSTRACT:

Background

The purpose of this study was to test the efficacy of cyclic Arg-Gly-Asp (RGD) peptide conjugated with polyionic complex nanomicelles as targeted therapy for glioma.

Methods

A stable cyclic RGD polyionic complex nanostructure, ie, a c(RGDfC) polyionic complex micelle, was synthesized and its biocompatibility with cultured neurons was assessed using a cell viability assay. Targeted binding to cultured glioma cells was evaluated by the CdTe quantum dot marking technique and a cell viability assay. The inhibitory effect of the nanomicelles against glioma cells was also evaluated, and their targeted migration into rat brain glioma cells and apoptotic effects were traced by the CdTe quantum dot marking and immunohistochemical staining.

Results

c(RGDfC) polyionic

SUBMITTER: Liu X 

PROVIDER: S-EPMC3383325 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature