Primary lateral sclerosis as progressive supranuclear palsy: diagnosis by diffusion tensor imaging.

ABSTRACT:

Background

Evaluating the integrity of white matter tracts with diffusion tensor imaging may differentiate primary lateral sclerosis from progressive supranuclear palsy.

Methods

Thirty-three prospectively recruited subjects had standardized evaluations and diffusion tensor imaging: 3 with primary lateral sclerosis who presented with features suggestive of progressive supranuclear palsy, 10 with probable or definite progressive supranuclear palsy, and 20 matched controls. We compared fractional anisotropy of the corticospinal tract, superior cerebellar peduncles, and body of the corpus callosum between groups.

Results

Both the primary lateral sclerosis and progressive supranuclear palsy subjects showed reduced fractional anisotropy in superior cerebellar peduncle and b

SUBMITTER: Coon EA 

PROVIDER: S-EPMC3383380 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature