CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection.

ABSTRACT:

Background

The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported.

Methods

CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area.

Results

Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and th

SUBMITTER: Andersen AB 

PROVIDER: S-EPMC3383481 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature