Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.

ABSTRACT:

Rationale

Fibroblast growth factor homologous factors (FHFs), a subfamily of fibroblast growth factors (FGFs) that are incapable of functioning as growth factors, are intracellular modulators of Na(+) channels and have been linked to neurodegenerative diseases. Although certain FHFs have been found in embryonic heart, they have not been reported in adult heart, and they have not been shown to regulate endogenous cardiac Na(+) channels or to participate in cardiac pathophysiology.

Objective

We tested whether FHFs regulate Na(+) channels in murine heart.

Methods and results

We demonstrated that isoforms of FGF13 are the predominant FHFs in adult mouse ventricular myocytes. FGF13 binds directly to, and colocalizes with, the Na(V)1.5 Na(+) channel in the sarcolemma of adu

SUBMITTER: Wang C 

PROVIDER: S-EPMC3383600 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature