Discovery of novel biomarker candidates for liver fibrosis in hepatitis C patients: a preliminary study.

ABSTRACT:

Background

Liver biopsy is the reference standard for assessing liver fibrosis and no reliable non-invasive diagnostic approach is available to discriminate between the intermediate stages of fibrosis. Therefore suitable serological biomarkers of liver fibrosis are urgently needed. We used proteomics to identify novel fibrosis biomarkers in hepatitis C patients with different degrees of liver fibrosis.

Methodology/principal findings

Proteins in plasma samples from healthy control individuals and patients with hepatitis C virus (HCV) induced cirrhosis were analysed using a proteomics technique: two dimensional gel electrophoresis (2-DE). This technique separated the proteins in plasma samples of control and cirrhotic patients and by visualizing the separated proteins we were

SUBMITTER: Gangadharan B 

PROVIDER: S-EPMC3383672 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature