Neighbor overlap is enriched in the yeast interaction network: analysis and implications.

ABSTRACT: The yeast protein-protein interaction network has been shown to have distinct topological features such as a scale free degree distribution and a high level of clustering. Here we analyze an additional feature which is called Neighbor Overlap. This feature reflects the number of shared neighbors between a pair of proteins. We show that Neighbor Overlap is enriched in the yeast protein-protein interaction network compared with control networks carefully designed to match the characteristics of the yeast network in terms of degree distribution and clustering coefficient. Our analysis also reveals that pairs of proteins with high Neighbor Overlap have higher sequence similarity, more similar GO annotations and stronger genetic interactions than pairs with low ones. Finally, we demonstrate tha

SUBMITTER: Feiglin A 

PROVIDER: S-EPMC3383679 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature