Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation.

ABSTRACT:

Background

Local microbial infections induced by multiple-drug-resistant bacteria in the orthopedic field can be intractable, therefore development of new therapeutic modalities is needed. Photodynamic therapy (PDT) is a promising alternative modality to antibiotics for intractable microbial infections, and we recently reported that PDT has the potential to accumulate neutrophils into the infected site which leads to resolution of the infection. PDT for cancer has long been known to be able to stimulate the innate and adaptive arms of the immune system.

Methodology/principal findings

In the present study, a murine methicillin-resistant Staphylococcus aureus (MRSA) arthritis model using bioluminescent MRSA and polystyrene microparticles was established, and both the therapeut

SUBMITTER: Tanaka M 

PROVIDER: S-EPMC3383702 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature