Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.

ABSTRACT: Homeodomain-containing transcription factors play a fundamental role in the regulation of numerous developmental and cellular processes. Their multiple regulatory functions are accomplished through context-dependent inputs of target DNA sequences and collaborating protein partners. Previous studies have well established the sequence-specific DNA binding to homeodomains; however, little is known about how protein partners regulate their functions through targeting homeodomains. Here we report the solution structure of the Hox homeodomain in complex with the cell-cycle regulator, Geminin, which inhibits Hox transcriptional activity and enrolls Hox in cell proliferative control. Side-chain carboxylates of glutamates and aspartates in the C terminus of Geminin generate an overall charge patter

SUBMITTER: Zhou B 

PROVIDER: S-EPMC3384217 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature