Frontostriatal functional connectivity in major depressive disorder.

ABSTRACT:

Background

Abnormalities of the striatum and frontal cortex have been reported consistently in studies of neural structure and function in major depressive disorder (MDD). Despite speculation that compromised connectivity between these regions may underlie symptoms of MDD, little work has investigated the integrity of frontostriatal circuits in this disorder.

Methods

Functional magnetic resonance images were acquired from 21 currently depressed and 19 never-disordered women during wakeful rest. Using four predefined striatal regions-of-interest, seed-to-whole brain correlations were computed and compared between groups.

Results

Compared to controls, depressed participants exhibited attenuated functional connectivity between the ventral striatum and both ventromedial p

SUBMITTER: Furman DJ 

PROVIDER: S-EPMC3384258 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature