How much can we learn about the function of bacterial rRNA modification by mining large-scale experimental datasets?

ABSTRACT: Modification of ribosomal RNA is ubiquitous among living organisms. Its functional role is well established for only a limited number of modified nucleotides. There are examples of rRNA modification involvement in the gene expression regulation in the cell. There is a need for large data set analysis in the search for potential functional partners for rRNA modification. In this study, we extracted phylogenetic profile, genome neighbourhood, co-expression and phenotype profile and co-purification data regarding Escherichia coli rRNA modification enzymes from public databases. Results were visualized as graphs using Cytoscape and analysed. Majority linked genes/proteins belong to translation apparatus. Among co-purification partners of rRNA modification enzymes are several candidates for exp

SUBMITTER: Sergiev PV 

PROVIDER: S-EPMC3384335 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature