A novel cost function to estimate parameters of oscillatory biochemical systems.

ABSTRACT: Oscillatory pathways are among the most important classes of biochemical systems with examples ranging from circadian rhythms and cell cycle maintenance. Mathematical modeling of these highly interconnected biochemical networks is needed to meet numerous objectives such as investigating, predicting and controlling the dynamics of these systems. Identifying the kinetic rate parameters is essential for fully modeling these and other biological processes. These kinetic parameters, however, are not usually available from measurements and most of them have to be estimated by parameter fitting techniques. One of the issues with estimating kinetic parameters in oscillatory systems is the irregularities in the least square (LS) cost function surface used to estimate these parameters, which is caus

SUBMITTER: Nabavi S 

PROVIDER: S-EPMC3384360 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature