Interleukin-10-819 promoter polymorphism in association with gastric cancer risk.

ABSTRACT:

Background

Potential functional allele T/C single nucleotide polymorphism (SNP) of Interleukin 10 (IL-10) promoter -819 (rs1800871) has been implicated in gastric cancer risk. We aimed to explore the role of T/C SNP of IL-10 -819 in the susceptibility to gastric cancer through a systematic review and meta-analysis.

Methods

Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. 11 studies were ultimately eligible for the meta-analysis of IL-10 -819 T/C SNP. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated.

Results

IL-10 -819 TT genotype is associat

SUBMITTER: Xue H 

PROVIDER: S-EPMC3384469 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature