Revealing the microscale spatial signature of dengue transmission and immunity in an urban population.

ABSTRACT: It is well-known that the distribution of immunity in a population dictates the future incidence of infectious disease, but this process is generally understood at individual or macroscales. For example, herd immunity to multiple pathogens has been observed at national and city levels. However, the effects of population immunity have not previously been shown at scales smaller than the city (e.g., neighborhoods). In particular, no study has shown long-term effects of population immunity at scales consistent with the spatial scale of person-to-person transmission. Here, we use the location of dengue patients' homes in Bangkok with the serotype of the infecting pathogen to investigate the spatiotemporal distribution of disease risk at small spatial scales over a 5-y period. We find evidence

SUBMITTER: Salje H 

PROVIDER: S-EPMC3386131 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature