Mathematical modeling of human glioma growth based on brain topological structures: study of two clinical cases.

ABSTRACT: Gliomas are the most common primary brain tumors and yet almost incurable due mainly to their great invasion capability. This represents a challenge to present clinical oncology. Here, we introduce a mathematical model aiming to improve tumor spreading capability definition. The model consists in a time dependent reaction-diffusion equation in a three-dimensional spatial domain that distinguishes between different brain topological structures. The model uses a series of digitized images from brain slices covering the whole human brain. The Talairach atlas included in the model describes brain structures at different levels. Also, the inclusion of the Brodmann areas allows prediction of the brain functions affected during tumor evolution and the estimation of correlated symptoms. The model

SUBMITTER: Suarez C 

PROVIDER: S-EPMC3386273 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature