Comparative effects of low-carbohydrate high-protein versus low-fat diets on the kidney.

ABSTRACT:

Background and objectives

Concerns exist about deleterious renal effects of low-carbohydrate high-protein weight loss diets. This issue was addressed in a secondary analysis of a parallel randomized, controlled long-term trial.

Design, setting, participants, and measurements

Between 2003 and 2007, 307 obese adults without serious medical illnesses at three United States academic centers were randomly assigned to a low-carbohydrate high-protein or a low-fat weight-loss diet for 24 months. Main outcomes included renal filtration (GFR) indices (serum creatinine, cystatin C, creatinine clearance); 24-hour urinary volume; albumin; calcium excretion; and serum solutes at 3, 12, and 24 months.

Results

Compared with the low-fat diet, low-carbohydrate high-protein consumption

SUBMITTER: Friedman AN 

PROVIDER: S-EPMC3386674 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature