Fibroblast growth factor 23 and Inflammation in CKD.

ABSTRACT:

Background and objectives

Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD.

Design, setting, participants, & measurements

The association between levels of FGF23 and the inflammatory markers IL-6, C-reactive protein (CRP), TNF-α, and fibrinogen was assessed in a cross-sectional analysis of 3879 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study between June 2003 and September 2008.

Results

FGF23 correlated directly with IL-6 (r=0.4), CRP (r=0.2), TNF-α (r=0.4), and fibrinogen (r=0.3; P<0.001 for each). In univariate and multivariable-adjusted

SUBMITTER: Munoz Mendoza J 

PROVIDER: S-EPMC3386678 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature