Expansion, folding, and abnormal lamination of the chick optic tectum after intraventricular injections of FGF2.

ABSTRACT: Comparative research has shown that evolutionary increases in brain region volumes often involve delays in neurogenesis. However, little is known about the influence of such changes on subsequent development. To get at this question, we injected FGF2--which delays cell cycle exit in mammalian neocortex--into the cerebral ventricles of chicks at embryonic day (ED) 4. This manipulation alters the development of the optic tectum dramatically. By ED7, the tectum of FGF2-treated birds is abnormally thin and has a reduced postmitotic layer, consistent with a delay in neurogenesis. FGF2 treatment also increases tectal volume and ventricular surface area, disturbs tectal lamination, and creates small discontinuities in the pia mater overlying the tectum. On ED12, the tectum is still larger in FGF2

SUBMITTER: McGowan LD 

PROVIDER: S-EPMC3386876 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature