Genomics-aided structure prediction.

ABSTRACT: We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences. A simple hybrid method, called DCA-fold, integrating DCA contacts with an accurate knowledge of local information (e.g., the local secondary structure) is sufficient to fold proteins in the range of 1-3 Å resolution.

SUBMITTER: Sulkowska JI 

PROVIDER: S-EPMC3387073 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature