Auditory cortex responses to clicks and sensory modulation difficulties in children with autism spectrum disorders (ASD).

ABSTRACT: Auditory sensory modulation difficulties are common in autism spectrum disorders (ASD) and may stem from a faulty arousal system that compromises the ability to regulate an optimal response. To study neurophysiological correlates of the sensory modulation difficulties, we recorded magnetic field responses to clicks in 14 ASD and 15 typically developing (TD) children. We further analyzed the P100m, which is the most prominent component of the auditory magnetic field response in children and may reflect preattentive arousal processes. The P100m was rightward lateralized in the TD, but not in the ASD children, who showed a tendency toward P100m reduction in the right hemisphere (RH). The atypical P100m lateralization in the ASD subjects was associated with greater severity of sensory abnormal

SUBMITTER: Orekhova EV 

PROVIDER: S-EPMC3387220 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature