Relaxation of adaptive evolution during the HIV-1 infection owing to reduction of CD4+ T cell counts.

ABSTRACT:

Background

The first stages of HIV-1 infection are essential to establish the diversity of virus population within host. It has been suggested that adaptation to host cells and antibody evasion are the leading forces driving HIV evolution at the initial stages of AIDS infection. In order to gain more insights on adaptive HIV-1 evolution, the genetic diversity was evaluated during the infection time in individuals contaminated by the same viral source in an epidemic cluster. Multiple sequences of V3 loop region of the HIV-1 were serially sampled from four individuals: comprising a single blood donor, two blood recipients, and another sexually infected by one of the blood recipients. The diversity of the viral population within each host was analyzed independently in distinct time po

SUBMITTER: Leal E 

PROVIDER: S-EPMC3387245 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature