Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D.

ABSTRACT:

Background

The adverse effects of corticosteroids on bone mineral accretion (BMA) have been well documented. Vitamin D insufficiency, a prevalent condition in the pediatric population, has also been associated with decreased bone mineral density (BMD).

Objective

We sought to determine whether children with asthma who have lower vitamin D levels are more susceptible to the negative effects of corticosteroids on BMD over time.

Methods

Children aged 5 to 12 years with mild-to-moderate asthma who participated in the Childhood Asthma Management Program were followed for a mean of 4.3 years. Total doses of inhaled corticosteroids and oral corticosteroids (OCSs) were recorded, serum 25-hydroxyvitamin D3 levels were measured at the beginning of the trial, and serial dual-ener

SUBMITTER: Tse SM 

PROVIDER: S-EPMC3387323 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature