PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.

ABSTRACT: Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the accumulation and activation of leukocytes in visceral adipose tissue (VAT) and ultimately other tissues, leading to metabolic abnormalities such as insulin resistance, type-2 diabetes and fatty-liver disease. Although invasion of VAT by pro-inflammatory macrophages is considered to be a key event driving adipose-tissue inflammation and insulin resistance, little is known about the roles of other immune system cell types in these processes. A unique population of VAT-resident regulatory T (Treg) cells was recently implicated in control of the inflammatory state of adipose tiss

SUBMITTER: Cipolletta D 

PROVIDER: S-EPMC3387339 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature