Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.

ABSTRACT:

Context

A genome-wide association study has identified three loci (five independent signals) that confer risk for polycystic ovary syndrome (PCOS) in Han Chinese women. Replication is necessary to determine whether the same variants confer risk for PCOS in women of European ancestry.

Objective

The objective of the study was to test whether these PCOS risk variants in Han Chinese women confer risk for PCOS in women of European ancestry.

Design

This was a case-control study.

Setting

The study was conducted at deCODE Genetics in Iceland and two academic medical centers in the United States.

Patients

Cases were 376 Icelandic women and 565 and 203 women from Boston, MA, and Chicago, IL, respectively, all diagnosed with PCOS by the National Institutes of Healt

SUBMITTER: Welt CK 

PROVIDER: S-EPMC3387396 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature