Functional variations in the ATM gene and susceptibility to differentiated thyroid carcinoma.

ABSTRACT:

Context

ATM is critical in response to ionizing radiation-induced DNA damage.

Objective

Variations in ATM are hypothesized to affect individual susceptibility to thyroid cancer. Our objective was to evaluate the association between ATM polymorphisms and thyroid cancer risk.

Design, participants, and methods

Six ATM single nucleotide polymorphisms (SNP) were genotyped in two independent case-control series including 592 patients with differentiated thyroid carcinoma (DTC) and 885 healthy individuals. An unconditional logistic regression model was applied to calculate odds ratios (OR) and 95% confidence intervals (CI) for each SNP with respect to risk of DTC and the combination effect of SNP on cancer risk.

Results

The risk-allele frequencies of all the SNP were

SUBMITTER: Xu L 

PROVIDER: S-EPMC3387410 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature