DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors.

ABSTRACT:

Context

It is not known whether there are any DNA methylation alterations in adrenocortical tumors.

Objective

The objective of the study was to determine the methylation profile of normal adrenal cortex and benign and malignant adrenocortical tumors.

Methods

Genome-wide methylation status of CpG regions were determined in normal (n = 19), benign (n = 48), primary malignant (n = 8), and metastatic malignant (n = 12) adrenocortical tissue samples. An integrated analysis of genome-wide methylation and mRNA expression in benign vs. malignant adrenocortical tissue samples was also performed.

Results

Methylation profiling revealed the following: 1) that methylation patterns were distinctly different and could distinguish normal, benign, primary malignant, and metasta

SUBMITTER: Rechache NS 

PROVIDER: S-EPMC3387424 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature