Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease: a randomized clinical trial comparing three regimens.

ABSTRACT:

Context

Vitamin D insufficiency [serum 25-hydroxyvitamin D (25OHD) concentration less than 20 ng/ml] is prevalent among children with inflammatory bowel disease (IBD), and its treatment has not been studied.

Objective

The aim of this study was to compare the efficacy and safety of three vitamin D repletion regimens.

Design and setting

We conducted a randomized, controlled clinical trial from November 2007 to June 2010 at the Clinical and Translational Study Unit of Children's Hospital Boston. The study was not blinded to participants and investigators.

Patients

Eligibility criteria included diagnosis of IBD, age 5-21, and serum 25OHD concentration below 20 ng/ml. Seventy-one patients enrolled, 61 completed the trial, and two withdrew due to adverse events.

I

SUBMITTER: Pappa HM 

PROVIDER: S-EPMC3387426 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature