Rapid testing of SNPs and gene-environment interactions in case-parent trio data based on exact analytic parameter estimation.

ABSTRACT: Case-parent trio studies concerned with children affected by a disease and their parents aim to detect single nucleotide polymorphisms (SNPs) showing a preferential transmission of alleles from the parents to their affected offspring. A popular statistical test for detecting such SNPs associated with disease in this study design is the genotypic transmission/disequilibrium test (gTDT) based on a conditional logistic regression model, which usually needs to be fitted by an iterative procedure. In this article, we derive exact closed-form solutions for the parameter estimates of the conditional logistic regression models when testing for an additive, a dominant, or a recessive effect of a SNP, and show that such analytic parameter estimates also exist when considering gene-environment intera

SUBMITTER: Schwender H 

PROVIDER: S-EPMC3387527 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature