Ontology highlight
ABSTRACT:
SUBMITTER: Chua JJ
PROVIDER: S-EPMC3387777 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Scientific reports 20120702
In mammalian neurons, targeting and translation of specific mRNAs in dendrites contribute to synaptic plasticity. After nuclear export, mRNAs designated for dendritic transport are generally assumed to be translationally dormant and activity of individual synapses may locally trigger their extrasomatic translation. We show that the long, GC-rich 5'-untranslated region of dendritic SAPAP3 mRNA restricts translation initiation via a mechanism that involves an upstream open reading frame (uORF). In ...[more]