Randomized controlled trial of cephalexin versus clindamycin for uncomplicated pediatric skin infections.

ABSTRACT:

Objective

To compare clindamycin and cephalexin for treatment of uncomplicated skin and soft tissue infections (SSTIs) caused predominantly by community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA). We hypothesized that clindamycin would be superior to cephalexin (an antibiotic without MRSA activity) for treatment of these infections.

Patients and methods

Patients aged 6 months to 18 years with uncomplicated SSTIs not requiring hospitalization were enrolled September 2006 through May 2009. Eligible patients were randomly assigned to 7 days of cephalexin or clindamycin; primary and secondary outcomes were clinical improvement at 48 to 72 hours and resolution at 7 days. Cultures were obtained and tested for antimicrobial susceptibilities, pulsed-field gel

SUBMITTER: Chen AE 

PROVIDER: S-EPMC3387913 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature