Prognostic model for survival in patients with metastatic renal cell carcinoma: results from the international kidney cancer working group.

ABSTRACT:

Purpose

To develop a single validated model for survival in metastatic renal cell carcinoma (mRCC) using a comprehensive international database.

Experimental design

A comprehensive database of 3,748 patients including previously reported clinical prognostic factors was established by pooling patient-level data from clinical trials. Following quality control and standardization, descriptive statistics were generated. Univariate analyses were conducted using proportional hazards models. Multivariable analysis using a log-logistic model stratified by center and multivariable fractional polynomials was conducted to identify independent predictors of survival. Missing data were handled using multiple imputation methods. Three risk groups were formed using the 25th and 75th percen

SUBMITTER: Manola J 

PROVIDER: S-EPMC3387987 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature