Shared gene expression alterations in prostate cancer and histologically benign prostate from patients with prostate cancer.

ABSTRACT: Prostate cancer (PCa) field effect alterations provide important clues regarding the initiation of these tumors and suggest targets for prevention or biomarkers for early detection. However, biomarkers of PCa field effects that have passed independent validation are lacking, largely because these alterations are subtle and difficult to distinguish from unrelated small changes in gene expression. We hypothesized that shared expression alterations in PCa and benign prostates containing PCa (BPCs) would have a higher potential for independent validation than alterations identified in BPCs alone. Expression analyses were performed on 37 PCas and 36 unmatched BPCs and were contrasted with 28 benign prostates (BPs) from patients free of PCa. Most of the protein-coding genes and nonexonic RNAs se

SUBMITTER: Kosari F 

PROVIDER: S-EPMC3388167 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature