Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray.

ABSTRACT:

Introduction

Septic-shock-associated acute kidney injury (SSAKI) carries high morbidity in the pediatric population. Effective treatment strategies are lacking, in part due to poor detection and prediction. There is a need to identify novel candidate biomarkers of SSAKI. The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI.

Methods

A retrospective cohort study compared microarray data representing the first 24 hours of admission for 179 children with septic shock with those of 53 age-matched normal controls. SSAKI was defined as a >200% increase of baseline serum creatinine, persistent to 7 days after admission.

Results

Patients with SSAKI (n = 3

SUBMITTER: Basu RK 

PROVIDER: S-EPMC3388679 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature