Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma.

ABSTRACT:

Introduction

The nucleotide-binding oligomerization domain-like receptor (NLR) family has been recognized as comprising intracellular pattern recognition receptors in which NLRP3 (NLR family, pyrin domain containing 3) plays an important role in the initiation of host immune inflammatory responses. The genetic variants have been recognized to be critical determinants of interindividual differences in both inflammatory responses and clinical outcomes in critical illness. However, little is known about the clinical relevance of NLRP3 gene polymorphisms in critical illness.

Methods

A total of 718 patients with major blunt trauma were included in this study. Six tag SNPs (tSNPs) were selected from the entire NLRP3 gene through construction of haplotype bins, and they were genoty

SUBMITTER: Zhang AQ 

PROVIDER: S-EPMC3388683 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature