Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.

ABSTRACT:

Background & aims

Staging inadequately predicts metastatic risk in patients with colon cancer. We used a gene expression profile derived from invasive, murine colon cancer cells that were highly metastatic in an immunocompetent mouse model to identify patients with colon cancer at risk of recurrence.

Methods

This phase 1, exploratory biomarker study used 55 patients with colorectal cancer from Vanderbilt Medical Center (VMC) as the training dataset and 177 patients from the Moffitt Cancer Center as the independent dataset. The metastasis-associated gene expression profile developed from the mouse model was refined with comparative functional genomics in the VMC gene expression profiles to identify a 34-gene classifier associated with high risk of metastasis and death from co

SUBMITTER: Smith JJ 

PROVIDER: S-EPMC3388775 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature