Identification of hsa-miR-335 as a prognostic signature in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignancy and primary cause of death in Chinese cancer patients. Recurrence is a major factor leading to treatment failure and low level of 5-year survival rate in GC patients following surgical resection. Therefore, identification of biomarkers with potential in predicting recurrence risk is the key problem of the prognosis in GC patients.

Patients and methods

A total of 74 GC patients were selected for systematic analysis, consisting of 31 patients with recurrence and 43 patients without recurrence. Firstly, miRNAs microarray and bioinformatics methods were used to characterize differential expressed miRNAs from primary tumor samples. Following, we used a ROC method to select signature with best sensitivity and spec

SUBMITTER: Yan Z 

PROVIDER: S-EPMC3388997 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature