Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers.

ABSTRACT:

Objective

This study aims at exploring the effects of sodium tungstate treatment on hypothalamic plasticity, which is known to have an important role in the control of energy metabolism.

Methods

Adult lean and high-fat diet-induced obese mice were orally treated with sodium tungstate. Arcuate and paraventricular nuclei and lateral hypothalamus were separated and subjected to proteomic analysis by DIGE and mass spectrometry. Immunohistochemistry and in vivo magnetic resonance imaging were also performed.

Results

Sodium tungstate treatment reduced body weight gain, food intake, and blood glucose and triglyceride levels. These effects were associated with transcriptional and functional changes in the hypothalamus. Proteomic analysis revealed that sodium tungstate modifie

SUBMITTER: Amigo-Correig M 

PROVIDER: S-EPMC3389016 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature