Characterizing multistationarity regimes in biochemical reaction networks.

ABSTRACT: Switch like responses appear as common strategies in the regulation of cellular systems. Here we present a method to characterize bistable regimes in biochemical reaction networks that can be of use to both direct and reverse engineering of biological switches. In the design of a synthetic biological switch, it is important to study the capability for bistability of the underlying biochemical network structure. Chemical Reaction Network Theory (CRNT) may help at this level to decide whether a given network has the capacity for multiple positive equilibria, based on their structural properties. However, in order to build a working switch, we also need to ensure that the bistability property is robust, by studying the conditions leading to the existence of two different steady states. In the

SUBMITTER: Otero-Muras I 

PROVIDER: S-EPMC3389020 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature