Structural basis for the selective permeability of channels made of communicating junction proteins.

ABSTRACT: The open state(s) of gap junction channels is evident from their permeation by small ions in response to an applied intercellular (transjunctional/transchannel) voltage gradient. That an open channel allows variable amounts of current to transit from cell-to-cell in the face of a constant intercellular voltage difference indicates channel open/closing can be complete or partial. The physiological significance of such open state options is, arguably, the main concern of junctional regulation. Because gap junctions are permeable to many substances, it is sensible to inquire whether and how each open state influences the intercellular diffusion of molecules as valuable as, but less readily detected than current-carrying ions. Presumably, structural changes perceived as shifts in channel condu

SUBMITTER: Ek-Vitorin JF 

PROVIDER: S-EPMC3389294 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature