Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls.

ABSTRACT:

Background

Brain dysfunction in prefrontal cortex (PFC) and dorsal striatum (DS) contributes to habitual drug use. These regions are constituents of brain networks thought to be involved in drug addiction. To investigate whether networks containing these regions differ between nicotine dependent female smokers and age-matched female non-smokers, we employed functional MRI (fMRI) at rest.

Methods

Data were processed with independent component analysis (ICA) to identify resting state networks (RSNs). We identified a subcortical limbic network and three discrete PFC networks: a medial prefrontal cortex (mPFC) network and right and left lateralized fronto-parietal networks common to all subjects. We then compared these RSNs between smokers and non-smokers using a dual regression

SUBMITTER: Janes AC 

PROVIDER: S-EPMC3389311 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature